Invasive micropapillary carcinoma: a distinct type of adenocarcinoma in the gastrointestinal tract. Guzinska-Ustymowicz K, Niewiarowska K, Pryczynicz A.
Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Verdu M, Roman R, Calvo M, Rodón N, García B, González M, Vidal A, Puig X. WHO classification of tumours editorial board, editor. Apoptosis has the potential to reciprocally produce MPC, PDCs, and TBs, with TGF-β1 involvement. No nuclear β-catenin positivity was found in any of the tumor cells.
Non-tumorous bud components, especially those in the deep layer, had poor ability to promptly acquire apoptosis resistance. However, apoptosis and M30 positivity were low in the TBs. Cells positive for apoptosis-related M30 were distributed mainly in the deep layer with a significant PDC and TB presence. Apoptosis occurred mainly at the TG and PDC peripheries in the middle and deep tumor layers, and transforming growth factor beta 1 (TGF-β1) positivity was evident in those tumor cells. Moreover, TG ruptures were scattered, with PDCs adjacent to them. In many of the tumor glands (TGs) of the MPC, empty spaces and tumor cell detachment toward the gland interior were observed. We examined the case using immunohistochemistry. However, we encountered a case of colonic MPC with frequent apoptosis. Epithelial–mesenchymal transition, which is involved in the cancer cell acquisition of apoptosis resistance, is closely linked with histological findings of MPC, PDCs, and tumor buds (TBs), with MPC and TBs considered as apoptosis-resistant features. Colorectal micropapillary carcinoma (MPC) exhibits aggressive biological characteristics, with empty spaces and reversed polarity, similar to the poorly differentiated clusters (PDCs) formed from detached cancer cells.
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